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. 2024 Aug 23;27(10):110624. doi: 10.1016/j.isci.2024.110624

Figure 1.

Figure 1

Robust RBD binding antibody responses elicited in the equine model

(A) Structural model of immunogens, Spike ferritin nanoparticle (SpFN) in blue and receptor binding domain ferritin nanoparticle (RFN) in red.

(B) Immunization schema for equine hyperimmune SARS-CoV-2-reactive sera generation (n = 12). Horses C9-C14 were immunized with SpFN, and horses C15-C20 were immunized with RFN, with CFA adjuvant for prime, and IFA for the subsequent two immunizations. Immunization schedules are depicted as square (150 μg dose at 0, 3, and 6 weeks), circle (500 μg dose at 0, 3, and 6 weeks), triangle (150 μg dose at 0, 4, and 8 weeks), and plus sign (500 μg dose at 0, 4, and 8 weeks).

(C and D) SARS-CoV-2 VoC RBD binding levels measured by BLI. (C) SpFN immunized group (blue), (D) RFN immunized group (red). Symbols are matched to the immunization schema shown in (B).