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. 2024 Aug 23;27(10):110624. doi: 10.1016/j.isci.2024.110624

Figure 2.

Figure 2

Sarbecovirus cross-reactive neutralization and binding capacity

(A) Pseudovirus neutralization (ID50 values) of WA-1, Alpha, Beta, Delta, Omicron BA.1, Omicron BA.5, Omicron XBB.1.5, and SARS-CoV-1. Thin lines represent individual animals, and the bold line depicts the geometric mean (blue, triangle: SpFN, red, circle: RFN).

(B) Correlation between SARS-CoV-2 WA-1 and SARS-CoV-1 Urbani pseudovirus neutralization titers (ID50), the black line depicts the locally weighted smoothing line and gray shading is the 95% confidence interval around the smoothing line.

(C) Correlation between BLI RBD-binding responses and pseudovirus neutralization titer (ID50), for each SARS-CoV-2 VoC and SARS-CoV-1. Pearson correlation coefficient calculation (r) assumed Gaussian distribution, and a two-tailed P value was calculated using GraphPad.