REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-GPX4 Antibody	Boster	Cat# BM5231; RRID: AB_3661639
Recombinant Anti-DDX5 antibody	abcam	Cat# ab126730; RRID: AB_11130291
Recombinant Anti-eEF1A1/EF-Tu+eEF1A1+eEF1AL3 antibody	abcam	Cat# ab157455; RRID: AB_3094654
Recombinant Anti-Collagen III antibody	abcam	Cat# ab184993; RRID: AB_2895112
Rabbit Anti-Fibronectin/Ugl-Y3 antibody	Bioss	Cat# bs-13455R; RRID: AB_3661640
smooth muscle actin specific Monoclonal antibody	Proteintech	Cat# 67735-1-Ig; RRID: AB_2918504
ACSL4 Rabbit mAb	ABclonal	Cat# A20414; RRID: AB_2909505
Anti-Cox2 PTGS2 Monoclonal Antibody	Boster	Cat# M00084-1; RRID: AB_3661638
KAT6B Rabbit pAb	ABclonal	Cat# A17116; RRID: AB_2770037
GATA1 Polyclonal antibody	Proteintech	Cat# 10917-2-AP; RRID: AB_2108279
Chemicals, peptides, and recombinant proteins
actinomycin D	MedChem Express	Cat # HY-17559
JQ-1	Selleck	Cat #S7110
MG-132	Selleck	Cat #S2619
Ferrostatin-1	Selleck	Cat #S7243
RSL3	Selleck	Cat #S8155
Critical commercial assays
Fluorescence In Situ Hybridization Kit	GenePharma	N/A
Cytoplasmic & Nuclear RNA Purification kit	NORGEN Biotrk Corp	Cat # 21000
RNA Immunoprecipitation (RIP) Kit	BersinBio	Cat # Bes5101
RNA pull-down kit	BersinBio	Cat # Bes5102
ChIP Assay Kit	Beyotime	Cat #P2078
Lipid Peroxidation MDA Assay Kit	Beyotime	Cat #S0131S
Glutathione Assay Kit	Sigma	Cat # CS0260
Ferrous Ion Content Assay Kit	Solarbio	Cat # BC5415
Experimental models: cell lines
Mouse pulmonary artery smooth muscle cells	Procell Life Science & Technology	N/A
Experimental models: organisms/strains
Male C57BL/6 mice	Changchun Yisi Experimental Animal Technology Limited	N/A
Oligonucleotides
Mus-circMyst4: Forward (5′–3′): CCCAGTGCTTTTCCGTCCTC	This paper	N/A
Mus-circMyst4: Reverse (5′–3′): CCAGGCAACGTGGAGAGTTG	This paper	N/A
Mus-Myst4: Forward (5′–3′): TAGCCTCTCGTGTCCTGTCA	This paper	N/A
Mus-Myst4: Reverse (5′–3′): CCCCTCCCCCAAAGTCAAAA	This paper	N/A
Mus-GPX4: Forward (5′–3′): GCCAAAGTCCTAGGAAACGC	This paper	N/A
Mus-GPX4: Reverse (5′–3′): CCGGGTTGAAAGGTTCAGGA	This paper	N/A
Mus-GPX4 pre-mRNA: Forward (5′–3′): GGCACGTCTGAACGAGTTATC	This paper	N/A
Mus-GPX4 pre-mRNA: Reverse (5′–3′): TAGGGGCACACACTTGTAGG	This paper	N/A
Mus-DDX5: Forward (5′–3′): CATTTCCATCGGTCCTTGC	This paper	N/A
Mus-DDX5: Reverse (5′–3′): AAGTAGAATCCTGCGGCGAC	This paper	N/A
Mus-Eef1a1: Forward (5′–3′): CGCAGGTGTTGTGAAAACCA	This paper	N/A
Mus-Eef1a1: Reverse (5′–3′): ACGTGTCCGATTACGACGAT	This paper	N/A
Mus-β-Actin: Forward (5′–3′): TCAGGTCATCACTATCGGCAAT	This paper	N/A
Mus-β-Actin: Reverse (5′–3′): AAAGAAAGGGTGTAAAACGCA	This paper	N/A
Software and algorithms
ImageJ	National Institutes of Health	N/A
GraphPad Prism 9	GraphPad Software	N/A