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. 2024 Sep 30;24:1211. doi: 10.1186/s12885-024-12973-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — Identification of the matrix stiffness-related ECM genes with prognostic significance in HCC. (A) Identification of the top 30 DEGs for HCC in the TCGA database. (B) Venn diagram showing 65 matrix stiffness-related ECM-related genes. (C-D) Heatmap and circle plot of KEGG analysis of matrix stiffness-related ECM genes; hsa04142, lysosome; hsa05135, Yersinia infection; hsa04330, Notch signalling pathway; hsa04110, cell cycle; hsa00970, aminoacyl-tRNA biosynthesis; hsa03320, PPAR signalling pathway; hsa05100, bacterial invasion of epithelial cells; hsa04062, chemokine signalling pathway; hsa05417, lipid and atherosclerosis; and hsa04666, Fc gamma R-mediated phagocytosis. (D) Mutational landscape of matrix stiffness-related ECM genes in the TCGA cohort. (E) The median TMB of matrix stiffness-related ECM genes. (F) Forest plot of univariate Cox regression analysis for matrix stiffness-related ECM genes with significant prognostic value