Fig. 4.

Evaluation of the accuracy of the matrix stiffness-related ECM gene prognostic signature in HCC. (A-B) Forest plot of univariate Cox regression analysis for different clinical factors and risk scores in the TCGA and ICGC cohorts. (C-D) Forest plot of multivariate Cox regression analysis for different clinical factors and risk scores in the TCGA and ICGC cohorts. (E) Distribution heatmap of 9 predictive matrix stiffness-related ECM genes and clinicopathological variables in the high- and low-risk groups. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.001; ns, not significant