Uvehammer 2007.

Methods	RCT. Unknown randomization technique. Blinding not stated.
Participants	Inclusion: Osteoarthrosis: 50 participants (54 knees). All of the femoral components were manufactured with an 80 mm stem and were only available in one size (size 2/medium). This made the series more homogeneous regarding biomechanical factors but excluded selection of participants with larger or smaller knees. Average age: 72 years. Fifteen participants were lost (16 knees).
Interventions	The femoral component fixation (cemented or uncemented with hydroxyapatite) and prosthesis design (three variations of the Freeman‐Samuelson knee replacement (Finsbury Orthopaedics Ltd): one with a rotating tibial insert, one with a medial femoral condyle representing part of a sphere articulating against a corresponding concave tibial polyethylene insert (FS1000), and the original standard version) were randomized, and the participants were randomized into one of the six treatment options. All of the tibial components were cemented. In 44 of the knees, a patellar component was inserted. Refobacin‐Palacos R bone cement (Biomet Orthopaedics Inc., Warsaw, Indiana) was prepared by vacuum mixing.
Outcomes	RSA (absolute values of rotation around the three orthogonal axes), HKA, and Hospital for Special Surgery knee score.
Notes	Duration of follow‐up: 2 years. No difference between the two types of fixation.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	This item was not mentioned in the trial report.
Allocation concealment (selection bias)	Low risk	Sealed envelopes were opened before the operation.
Was the patient blinded?	Unclear risk	This item was not mentioned in the trial report.
Was the surgeon blinded?	High risk	It is impossible to blind the surgeon to prosthesis fixation.
Was the outcome assessor blinded?	Unclear risk	This item was not mentioned in the trial report.
Was the withdrawal/drop‐out rate described, acceptable (<20%), and comparable in both groups?	Low risk	The withdrawal/drop‐out rate was described, was comparable in both groups and was not acceptable. Missing outcome data were balanced in numbers among intervention groups with similar reasons for missing data among the groups.
Selective reporting (reporting bias)	Low risk	The study protocol is available, and all of the study’s prespecified (primary and secondary) outcomes that were of interest in the review were reported in the prespecified manner.

RCT = randomoized controlled trial

RSA = roentgen stereophotogrammetric analysis

MTPM = maximum total point motion

RA = rheumatoid arthritis

HKA = hip‐knee‐ankle‐angle