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. 2024 Sep 29;17:89. doi: 10.1186/s13045-024-01609-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — SMARCA4 inactivation alters chromatin accessibility in NE-high SCLC. A Heatmap showing ATACseq chromatin accessibility changes (FDR:0.01, FC > 1.5) in H82 and H146 cells after treatment with FHD-286 (100 nM, 14 days). B Enrichment of neuronal and NE HOMER transcription factor-binding DNA motifs in ATAC-seq peaks lost after treatment with FHD-286 (100 nM, 14 days). The percentage indicates the amount of target sequences with motif. C Genomic localization of lost and gained accessible sites upon FHD-286 treatment in H82 and H146 cells. D ATACseq genome tracks of NEUROD1, SYP and CHGA in H82 and H146 cells after treatment with FHD-286. Peaks with a significant reduction in chromatin accessibility are indicated with arrows. E Enrich analysis applied to all genes with lost sites (across all gene body) following FHD-286 treatment. Top 10 GO Biological processes enriched are shown. See also Fig. S4