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. 2024 Sep 16;121(39):e2321321121. doi: 10.1073/pnas.2321321121

Table 2.

Standard depression questionnaire (PHQ-9; left column) and modified depression-related experience questions (right column)

PHQ-9 question categories (“Over the last 2 weeks, how often have you been bothered by any of the following problems?”) Depression-related experience questions
Feeling down, depressed, or hopeless Could you describe your general mood in the past 2 weeks? Has your mood been higher or lower than usual? Are there any particular emotions that you have been feeling a lot lately?
Little interest or pleasure in doing things Take a moment to think about things you usually enjoy. How would you describe your level of interest in these things in the past 2 weeks? Has it been higher or lower than usual?
Poor appetite or overeating How have you been eating in the past 2 weeks? Is there anything that has been different compared to usual (e.g., eating more or less than usual)?
Trouble falling or staying asleep, or sleeping too much How would you describe your sleep patterns lately? Is there anything that has been different compared to usual?
Moving or speaking so slowly that other people could have noticed. Or the opposite—being so fidgety or restless that you have been moving around a lot more than usual In the past 2 weeks, has sitting still, moving, or talking been harder or easier than usual?
Feeling tired or having little energy Sometimes we feel tired and exhausted, and sometimes we feel full of energy. How would you describe your energy level in the past 2 weeks?
Feeling bad about yourself—or that you are a failure or have let yourself or your family down How have you been feeling about yourself in the past 2 weeks?
Trouble concentrating on things, such as reading the newspaper or watching television How would you describe your thinking, concentration, and decision-making in the past 2 weeks? Is there anything that has been harder or easier than usual?
Thoughts that you would be better off dead, or of hurting yourself Think about your life overall. Is there anything that you are particularly satisfied or dissatisfied with?