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CXCR4-targeted theranostics protocol for hematological malignancies. CXCR4-directed PET/CT allows for identifying patients eligible for CXCR4-targeted RLT using 90Y-pentixather, which exerts antilymphoma effect through β-radiation–induced double-strand breaks of the DNA. After desired aplasia due to CXCR4 RLT-mediated destruction of the stem cell niche, conditioning regimen (CON) allows for further aplasia, followed by HSCT and engraftment. Created with biorender.com.
