TABLE 2.
Changes of Laboratory Parameters Relevant for Myeloablative Effects, TLS, and Off-Target Effects
| Parameter | Day 0 to Day 2 | Day 0 to CON | ||
|---|---|---|---|---|
| % Change | P | % Change | P | |
| Myeloablative effects | ||||
| Leukocytes | −24.5 | 0.003 | −79.4 | 0.0001 |
| Hemoglobin | −9 | <0.0001 | −8.7 | 0.005 |
| Platelets | −19.2 | 0.002 | −43.1 | 0.0005 |
| Granulocytes | −16.9 | 0.08 | −70.3 | 0.0005 |
| TLS | ||||
| Uric acid | −3.4 | 0.70 | −25.1 | 0.049 |
| Potassium | −2.3 | 0.33 | −0.8 | 0.66 |
| Phosphate | 12.5 | 0.2 | −1.2 | 0.75 |
| Calcium | −2.6 | 0.16 | −2.3 | 0.02 |
| Off-target effects | ||||
| Creatinine | −2.9 | 0.31 | −15.1 | 0.001 |
| GFR | 2.7 | 0.45 | 18.9 | 0.001 |
| GGT | −2.8 | 0.32 | −6.2 | 0.18 |
| GOT | 1.8 | 0.87 | −25.3 | 0.003 |
| GPT | −6.1 | 0.18 | −29.5 | 0.0007 |
Mean percentage changes of laboratory parameters between the day of RLT (day 0), day 2 after RLT, and day of CON. Except for granulocytes, myeloablative effects with significant drop occurred already 2 days after RLT. None of the patients experienced laboratory-defined TLS according to Cairo and Bishop.19 Changes in renal and functional parameters were also not indicative for kidney or liver failure. Significant P values are marked in bold.