Table 4.
Association of CFAP43 and TEX14 SNPs with male infertility.
| SNP | Genotype | Control (n = 195) | Case (n = 206) | OR | 95% CI | P value |
|---|---|---|---|---|---|---|
|
CFAP43 rs17116635 |
Additive | .84* | ||||
| CC | 160 (82.05%) | 171 (83.01%) | 1.00 | |||
| CT | 34 (17.44%) | 35 (16.99%) | 0.96 | 0.57–1.63 | .89** | |
| TT | 1 (0.51%) | 0 (0.00%) | 0.00 | 0.00–36.72 | .49* | |
| Recessive | ||||||
| CC + CT | 194 (99.49%) | 206 (100.00%) | 1.00 | |||
| TT | 1 (0.51%) | 0 (0.00%) | 0.00 | 0.00–36.92 | .49* | |
| Dominant | ||||||
| CC | 160 (82.05%) | 171 (83.01%) | 1.00 | |||
| CT + TT | 35 (17.95%) | 35 (16.99%) | 0.94 | 0.54–1.62 | .90** | |
| Allele | ||||||
| C | 354 (90.77%) | 377 (91.50%) | 1.00 | |||
| T | 36 (9.23%) | 35 (8.50%) | 0.91 | 0.56–1.49 | .71** | |
|
CFAP43 rs10883979 |
Additive | .07** | ||||
| AA | 128 (65.64%) | 137 (66.50%) | 1.00 | |||
| AG | 56 (28.72%) | 66 (32.04%) | 1.10 | 0.72–1.70 | .66** | |
| GG | 11 (5.64%) | 3 (1.46%) | 0.27 | 0.06–0.89 | .03 ** | |
| Recessive | ||||||
| AA + AG | 184 (94.36%) | 203 (98.54%) | 1.00 | |||
| GG | 11 (5.64%) | 3 (1.46%) | 0.26 | 0.06–0.85 | .02 ** | |
| Dominant | ||||||
| AA | 128 (65.64%) | 137 (66.50%) | 1.00 | |||
| AG + GG | 67 (34.36%) | 69 (33.50%) | 0.96 | 0.62–1.49 | .92** | |
| Allele | ||||||
| A | 312 (80.00%) | 340 (82.52%) | 1.00 | |||
| G | 78 (20.00%) | 72 (17.48%) | 0.85 | 0.59–1.21 | .36** | |
|
TEX14 rs79813370 |
Additive | .001 * | ||||
| GG | 125 (64.10%) | 166 (80.58%) | 1.00 | |||
| GT | 64 (32.82%) | 37 (17.96%) | 0.44 | 0.27–0.69 | <.001 ** | |
| TT | 6 (3.08%) | 3 (1.46%) | 0.38 | 0.06–1.81 | .19* | |
| Recessive | ||||||
| GG + GT | 189 (96.92%) | 203 (98.54%) | 1.00 | |||
| TT | 6 (3.08%) | 3 (1.46%) | 0.47 | 0.07–2.22 | .33* | |
| Dominant | ||||||
| GG | 125 (64.10%) | 166 (80.58%) | 1.00 | |||
| GT + TT | 70 (35.90%) | 40 (19.42%) | 0.43 | 0.27–0.69 | <.001 ** | |
| Allele | ||||||
| G | 314 (80.51%) | 369 (89.56%) | 1.00 | |||
| T | 76 (19.49%) | 43 (10.44%) | 0.48 | 0.32–0.72 | <.001 ** | |
|
TEX14 rs34818467 |
Additive | .19* | ||||
| AA | 151 (77.44%) | 147 (71.36%) | 1.00 | |||
| AG | 41 (21.03%) | 58 (28.16%) | 1.45 | 0.92–2.31 | .11** | |
| GG | 3 (1.54%) | 1 (0.49%) | 0.34 | 0.01–4.33 | .62* | |
| Recessive | ||||||
| AA + AG | 192 (98.46%) | 205 (99.51%) | 1.00 | |||
| GG | 3 (1.54%) | 1 (0.49%) | 0.31 | 0.01–3.94 | .36* | |
| Dominant | ||||||
| AA | 151 (77.44%) | 147 (71.36%) | 1.00 | |||
| AG + GG | 44 (22.56%) | 59 (28.64%) | 1.38 | 0.86–2.22 | .17** | |
| Allele | ||||||
| A | 343 (87.95%) | 352 (85.44%) | 1.00 | |||
| G | 47 (12.05%) | 60 (14.56%) | 1.24 | 0.83–1.88 | .30** | |
95% CI = 95% confidence interval, n = number, OR = odds ratio, SNP = single nucleotide polymorphism.
P < .05 (in bold) indicates statistical significance.
*
P values calculated by Fisher’s exact test.
**
P values calculated by Chi-squared test.