Table 2.

AUC and concentration of ACh that provokes a 50% dilation (logEC₅₀) for EDD

	Serum Exposure				Kruskal–Wallis Test
	Young human	ML/O human	Young dolphin	ML/O dolphin	P value
N	10	10	16	4
AUC	301 [287–362]	278 [232–323]	322 [304–335]	333 [330–350]	0.080
logEC50	−7.2 [−7.7 to −7.0]	−7.1 [−7.4 to −6.3]	−7.3 [−7.5 to −7.2]	−7.5 [−7.7 to −7.4]	0.215

Data were summarized using the medians and interquartile range (IQR = 25th−75th percentile); N, number of human and dolphin subjects, respectively. ML/O, midlife/older. Area under the curve (AUC) and concentration of acetylcholine (ACh) provoke a 50% dilation (logEC₅₀) for endothelium-dependent dilation (EDD).