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. 2024 Sep 17;15:1445653. doi: 10.3389/fimmu.2024.1445653

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Copyright © 2024 Byrne, Gu, Garcia-Leon, Gaillard, Saini, Alalwan, Tomás-Cortázar, Kenny, Donohue, Reynolds, O’Gorman, Landay, Doran, Stemler, Koehler, Cox, Olesen, Lelievre, O’Broin, Savinelli, Feeney, O’Halloran, Cotter, Horgan, Kelly, Sadlier, de Barra, Cornely, Gautier, Mallon and All Ireland Infectious Diseases cohort study and VACCELERATE consortium

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SARS-CoV-2–specific antibody titres and relationship with incident infection. (A) Significantly higher SARS-CoV-2–specific anti-RBD, anti-S1, and anti-S2 titres at day 14. *p ≤ 0.0001 compared to pre-vaccine response by Wilcoxon signed-rank test. (B) There was no significant difference in anti-RBD IgG, anti–spike-subunit-1 IgG, or anti–spike-subunit-2 IgG titres at day 14 in those who developed infection and those who did not develop infection. Bars represent median and interquartile range. P-values calculated by Mann–Whitney U test are shown above each comparison. D0, day 0; D14, day 14; RBD, receptor-binding domain; S, spike; S1, spike subunit 1; S2, spike subunit 2; BAU, binding antibody unit; IgG Immunoglobulin G.