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. 2024 Sep 17;15:1445653. doi: 10.3389/fimmu.2024.1445653

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Copyright © 2024 Byrne, Gu, Garcia-Leon, Gaillard, Saini, Alalwan, Tomás-Cortázar, Kenny, Donohue, Reynolds, O’Gorman, Landay, Doran, Stemler, Koehler, Cox, Olesen, Lelievre, O’Broin, Savinelli, Feeney, O’Halloran, Cotter, Horgan, Kelly, Sadlier, de Barra, Cornely, Gautier, Mallon and All Ireland Infectious Diseases cohort study and VACCELERATE consortium

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Higher SARS-CoV-2–specific memory B-cell frequencies determine survival from SARS-CoV-2 infection. (A) Kaplan–Meier survival curve based on the median SARS-CoV-2 full spike–specific memory B-cell frequencies (33.62% total IgG-secreting B cells) at day 14 after the third-dose SARS-CoV-2 vaccination and incident infection. (B) Kaplan–Meier survival curve based on the median SARS-CoV-2 RBD memory B-cell frequencies (0.95% total IgG-secreting B cells) at day 0 after SARS-CoV-2 vaccination and incident infection. Survival analysis p-value calculated by log-rank (Mantel–Cox) test.