Table 2.
Pharmacokinetics of ribociclib by CYP3A5 phenotypea
| CYP3A5 IM/NM n = 7 | CYP3A5 PM n = 7 | P-value | |
|---|---|---|---|
| AUCtau (h*ng/mL) | 43,546 (35298, 46647) | 39,230 (18745, 57566) | 0.38 |
| AUC0-6 h (h*ng/mL) | 14,907 (8254, 15245) | 11,102 (6143, 13651) | 0.26 |
| Cmax (ng/mL) | 3,140 (1980, 3540) | 3,020 (1300, 3470) | 0.46 |
| Tmax (h) | 2.0 (2.0, 4.0) | 3.8 (2.0, 5.9) | 0.48 |
AUC area under the curve, Cmax maximum concentration, IM/NM intermediate metabolizers/normal metabolizers, PM poor metabolizers Tmax time to reach maximum concentration
aMedian and interquartile range are shown for continuous data