Table 3.
Adverse events of interest by CYP3A5 phenotype
| CYP3A5 IM/NM n = 7 | CYP3A5 PM n = 7 | |||
|---|---|---|---|---|
| Toxicity (any grade) | Toxicity (grade 3+) | Toxicity (any grade) | Toxicity (grade 3+) | |
| Any AE | 7 | 2 | 5 | 2 |
| Hematologic | ||||
| Neutropenia | 0 | 0 | 3 | 1 |
| Thrombocytopenia | 1 | 0 | 0 | 0 |
| Leukopenia | 3 | 1 | 2 | 1 |
| Anemia | 2 | 1 | 0 | 0 |
| Gastrointestinal | ||||
| Diarrhea | 1 | 0 | 2 | 0 |
| Nausea | 3 | 1 | 2 | 1 |
| Vomiting | 2 | 1 | 2 | 1 |
| Transaminitis | 1 | 0 | 1 | 1 |
| Constipation | 1 | 0 | 1 | 0 |
| Abdominal pain | 0 | 0 | 1 | 0 |
| Melena | 1 | 0 | 0 | 0 |
| Mucositis | 1 | 0 | 0 | 0 |
| Cardiac | ||||
| QTc Prolongation | 3 | 0 | 1 | 0 |
| Palpitations | 1 | 0 | 0 | 0 |
| Sinus tachycardia | 1 | 0 | 0 | 0 |
| Metabolism and nutrition disorders | ||||
| Arthralgia | 1 | 0 | 1 | 0 |
| Back pain | 0 | 0 | 1 | 0 |
| Bone pain | 1 | 0 | 0 | 0 |
The list of specific types of AEs has been abbreviated. A complete list of recorded adverse events are available in Supplementary table 3.
AE adverse events, IM/NM intermediate metabolizers/normal metabolizers, PM poor metabolizers