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. 2024 Sep 30;5(10):e727. doi: 10.1002/mco2.727

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© 2024 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Ovarian transcriptome analysis reveals the mechanism through which NMN inhibits ovarian aging. (A) Heatmap showing the gene expression profiles in the ovaries of young, aged, and aged + NMN groups of mice (n = 4 mice per group). (B and C) Volcano plots depicting the differentially expressed genes (DEGs) in aged versus young and aged + NMN versus aged groups of mouse ovaries. Some highly expressed DEGs are listed. Downregulated genes are indicated in blue, and upregulated genes are indicated in red. (D–G) Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of upregulated and downregulated DEGs in the ovaries of aged versus young and aged + NMN versus aged mice. (H–K) Gene Ontology (GO) enrichment analysis of upregulated and downregulated DEGs in the ovaries of aged mice versus young mice and aged + NMN mice.