Fig. 3. Transcription factor reprogramming of prostate cancer subtypes.

a Luminal score based on transcript expression using scaled summative z-score. b Neuroendocrine score based on transcript expression using Pearson correlation. c Heatmap of transcriptome expression of pioneer transcription factors. Log2 fold changes in the transcriptome (d) and proteome (e) of transcription factors from (c) and four CRPC subtype classifications³⁰ CRPC-AR, -NE, -WNT (Wnt signaling), or -SCL (stem cell-like) (Supplementary Fig 4). Heatmaps of transcriptome and proteome as indicated of predicted FOXA1 (f) or NFYB (g) direct targets with summative z-scores indicated.