Fig. 1. Gilteritinib inhibits proliferation of lung cancer cells in vitro and in vivo.

A Viability of A549 and H1650 cells after 48 h culture in varying concentrations of gilteritinib, and the IC50 was calculated. B Viability of A549 and H1650 cells after varying time culture with gilteritinib. C A549 cells were subcutaneously injected into mice, and mice received administration of 1 or 5 mg/kg gilteritinib. The antitumor effect of gilteritinib was evaluated using a tumor growth curve. D Images of the excised tumors from control and treatment groups are shown. E The tumor weight of each group is compared. F PCNA staining of tumors from untreated or gilteritinib-treated mice. G Mouse body weight was measured. ***P < 0.001. ns no significant difference.