Table 3.
Top constitutional phenotypes found in the BDLP and SMP
| Class | Proportion of associations | |
|---|---|---|
| BDLP | SMP | |
| Pain (HP:0012531) | 0.68 | 0.74 |
| Abdominal pain (HP:0002027) | 0.11 | 0.12 |
| Limb pain (HP:0009763) | 0.08 | 0.13 |
| Fatigue (HP:0012378) | 0.07 | 0.05 |
| Impairment of activities of daily living (HP:0031058) | 0.06 | 0.05 |
| Arthralgia (HP:0002829) | 0.05 | 0.05 |
| Back pain (HP:0003418) | 0.05 | 0.15 |
| Myalgia (HP:0003326) | 0.05 | 0.04 |
| Impaired continence (HP:0031064) | 0.05 | 0.05 |
| Chest pain (HP:0100749) | 0.04 | 0.03 |
| Chills (HP:0025143) | 0.04 | 0 |
| Lower limb pain (HP:0012514) | 0.04 | 0.08 |
| Pain in head and neck region (HP:0046506) | 0.04 | 0.04 |
| Night sweats (HP:0030166) | 0.02 | 0.04 |
| Dyspepsia (HP:0410281) | 0.01 | 0.04 |
| Urinary incontinence (HP:0000020) | 0.02 | 0.05 |
| Low back pain (HP:0003419) | 0.02 | 0.05 |
| Sciatica (HP:0011868) | 0.01 | 0.05 |
| Neck pain (HP:0030833) | 0.01 | 0.04 |
| Chronic pain (HP:0012532) | 0.03 | 0.04 |
| Halitosis (HP:0100812) | 0.01 | 0.04 |
Proportion of associations is the percentage of constitutional symptom phenotype associations that were equivalent to or more specific than the named phenotype. Criteria for inclusion was at least 0.04 proportion of constitutional symptoms in either SMP or BDLP.