Fig. 4. Inference of regulatory allosteric and TF regulations after glucose administration.

A The inferred allosteric regulations of metabolic enzymes by the glucose-responsive metabolites. The metabolites serving as activators (orange) and inhibitors (blue) in the row labels regulate metabolic enzyme in the column labels. Bar charts on the left are the number of regulatory metabolites allosterically regulating each enzyme. The bar charts at the bottom are the number of enzymes allosterically regulated by each metabolite. B The inferred TF regulation of dose-dependent glucose-responsive genes by TFs using literature curations. The row labels are the dose-dependent glucose-responsive genes, regulated by the inferred TFs in the column label.