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. 2024 Sep 30;10:107. doi: 10.1038/s41540-024-00437-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 6 — A The regulatory transomic network for dose-dependent glucose-responsive metabolic reactions. The left diagram represents the network as colored nodes in the layers and edges between the layers. Colored nodes represent the responsiveness of dose-dependent glucose-responsive molecules: Orange, high glucose sensitivity and rapid; Pink, high glucose sensitivity and slow; Light green, low glucose sensitivity and rapid; Aquamarine, low glucose sensitivity and slow. Colored edges represent interlayer regulatory connections: Red, upregulated regulations; Blue, downregulated regulations; Purple, both upregulated and downregulated regulations; Gray, other regulations such as TF regulations and ambiguous regulations. The numbers of each type of glucose-responsive node and edge are shown with the same colors in the network summary to the right. The insulin signal layer is the insulin signaling pathway constructed in our previous phosphoproteomic study²⁵. The enzyme, reaction, and metabolite layers are organized into a global metabolic pathway (mmu01100) in the KEGG database. B The condensed dose-dependent glucose-responsive regulatory transomic network of the hepatic response to glucose in mice liver. The color of the outer circle of nodes represents the response time of a glucose-responsive molecule or the share of classified response time that is connected to a pathway (Yellow, rapid; Aquamarine, slow). The color of the inner circle of nodes represents the glucose sensitivity of a glucose-responsive molecule or the share of classified glucose sensitivity that is connected to a pathway (Orange, high glucose sensitivity; Blue, low glucose sensitivity). The color of the edges represents the responsive pattern of each regulation (Red, high glucose sensitivity; Blue, low glucose sensitivity). Dashed boxes show the type of metabolism these pathways. C The number of dose-dependent glucose-responsive reactions classified according to their glucose responsiveness across various types of metabolism. (e.g., carbohydrate metabolism, amino acid metabolism).