FIG. 4.
Infectious titers of sera from Gag-SN-expressing Mov mice are reduced by 2- to 10-fold. Infectious Mo-MuLV titers of sera from Gag-SN-expressing Mov mice were compared with those of their Mov siblings lacking gag-SN. Sera of five different litters were collected every 7 to 15 days up to several months, and infectious titers were determined by a focus formation assay. The litters analyzed result from crosses illustrated in Fig. 3 (upper right corner of each graph). n1 and n2 reflect number of animals compared in each graph. Each graph reflects the mean infectious titers in sera from singly transgenic Mov13 mice (black curve) and their doubly transgenic siblings (red curve). In the case of litter 5, sera were harvested over 85 days. Because of the large number of samples, sera of this litter were assayed in two independent focus formation assays.