FIG. 7.

Life spans of doubly transgenic Gag-SN-expressing Mov mice are extended relative to those of their singly transgenic Mov littermates. (A to F) KM survival plots comparing singly transgenic Mov13 (A to C) and Mov14 (D to F) mice (+/+ [black curve]) with their doubly transgenic Mov13 and Mov14 (gag-SN/+ [red curve]) littermates. Life spans of doubly transgenic Mov13 and Mov14 mice (gag-SN/+) of line E (A and D, respectively) and line F (B and E, respectively) were compared independently and collectively (C and F) with those of their singly transgenic (+/+) Mov13 and Mov14 littermates. The mean life span of singly transgenic Mov13 and Mov14 mice, 126 and154 days, respectively, is prolonged to 183 and 171 days in line E and 184 and 187 days in line F, respectively. The colors of the genotype and n correspond to the colors of the KM curves. p, significance of the difference in longevity between the two groups of mice.