| Only published adjusted hazard ratio |
7 |
0.80 (95% CI 0.68─0.96, P = 0.01) |
| Only studies with ‘overall survival’ as the primary outcome |
15 |
0.81 (95% CI 0.73─0.89, P < 0.001) |
| <50 years old (EOPC) cut off |
12 |
0.86 (95% CI 0.79─0.93, P = 0.0003) |
| <45 years old (EOPC) cut off |
3 |
0.88 (95% CI 0.85─0.91, P < 0.001) |
| <40 years old (EOPC) cut off |
2 |
0.47 (95% CI 0.42─0.54, P < 0.001) |
| <50 years old (EOPC) vs. >50 years old (AOPC) only |
11 |
0.86 (95% CI 0.79─0.93, P = 0.0003) |
| <45 years old (EOPC) vs. >45 years old (AOPC) only |
2 |
0.88 (95% CI 0.85─0.91, P < 0.001) |
| Adjusted for treatment received |
8 |
0.82 (95% CI 0.74─0.92, P < 0.001) |
| Adjusted for cancer stage |
12 |
0.80 (95% CI 0.73─0.87, P < 0.001) |
| Adjusted for comorbidities |
1 |
0.87 (95% CI 0.85─0.88, P < 0.001) |
| Studies with propensity-score based method |
4 |
0.95 (95% CI 0.81─1.12, P = 0.56) |
| Studies with Cox regression method |
9 |
0.79 (95% CI 0.70─0.88, P < 0.001) |
