Table 3.
Associations between LPL and PPARα genotypes and laboratory parameters using multinominal logistic regression analysis
| Genotype | Variable | Coefficient | SE | z-statistic | Lower | Upper | Exp(b) | P |
|---|---|---|---|---|---|---|---|---|
| LPL genotypes | ||||||||
| TT related to GG | BMI | 0.04 | 0.02 | 1.80 | –0.004 | 0.09 | 1.04 | 0.0717 |
| W/H | 1.81 | 1.30 | 1.39 | –0.73 | 4.36 | 6.14 | 0.1631 | |
| TC | –0.36 | 0.14 | –2.42 | –0.65 | –0.06 | 0.69 | 0.0154* | |
| TG | –0.11 | 0.18 | –0.64 | –0.47 | 0.24 | 0.88 | 0.5212 | |
| HDL | 1.55 | 0.81 | 1.91 | –0.03 | 3.15 | 4.75 | 0.0555 | |
| LDL | –0.66 | 0.22 | –2.90 | –1.10 | –0.21 | 0.51 | 0.0036* | |
| TT related to TG | BMI | –0.03 | 0.03 | –1.08 | –0.10 | 0.03 | 0.96 | 0.2777 |
| W/H | 3.95 | 1.26 | 3.11 | 1.47 | 6.44 | 52.37 | 0.0018* | |
| TC | 0.06 | 0.14 | 0.45 | –0.21 | 0.34 | 1.06 | 0.6478 | |
| TG | 0.60 | 0.19 | 3.14 | 0.22 | 0.97 | 1.82 | 0.0016* | |
| HDL | –0.62 | 0.62 | –0.99 | –1.86 | 0.60 | 0.53 | 0.3196 | |
| LDL | –0.08 | 0.20 | –0.40 | –0.48 | 0.32 | 0.92 | 0.6882 | |
| PPARα genotypes | ||||||||
| GC related to GG | BMI | 0.08 | 0.02 | 3.68 | 0.03 | 0.12 | 1.08 | 0.0002* |
| W/H | –6.62 | 2.95 | –2.24 | –12.42 | –0.83 | 0.001 | 0.0250* | |
| TC | 0.12 | 0.13 | 0.92 | –0.14 | 0.39 | 1.13 | 0.3500 | |
| TG | –0.07 | 0.17 | –0.46 | –0.41 | 0.25 | 0.92 | 0.6446 | |
| HDL | –0.06 | 0.62 | –0.10 | –1.28 | 1.15 | 0.93 | 0.9139 | |
| LDL | 0.31 | 0.20 | 1.53 | –0.08 | 0.71 | 1.36 | 0.1237 |
*P<0.05; 95% confidence interval.
LPL, lipoprotein lipase enzyme; PPARα, peroxisome proliferator-activated receptor α; SE, standard error; T, thymine; G, guanine; BMI, body mass index; W/H, waist-to-hip ratio; TC, total cholesterol; TG, triglyceride; HDL, high-density lipoprotein; LDL, low-density lipoprotein; C, cytosine.