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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Exp Gerontol. 2021 May 19;151:111416. doi: 10.1016/j.exger.2021.111416

Fig. 2.

Fig. 2.

Angiotensin II for AAA induction in aged mice and effects of oral senolytic agents. Angiotensin II (Ang II) increased abdominal aortic luminal diameter in aged mice consistent with AAA induction, measured in vivo by ultrasound (A, C) or by histology (H&E, B, D). Senolytic agents dasatinib and quercetin (D + Q) attenuated the increase in aortic diameter with Ang II. Boxplots show the 25th and 75th percentiles (box), median (line), and whiskers defined by largest and smallest values within 1.5 times the interquartile range with individual points representing values beyond this range from N = 7–13 mice per treatment group. * indicated significantly (P < 0.05) different from Ang II −, D + Q−. ϕ represents indicated significantly (P < 0.05) different from Ang II +, D + Q−.