TABLE 2.

Median number of organ systems involved compared to other studies. Median (number in group). Statistical calculations based on chi square analysis between the stated groups.

	This study	Ye et al. (2022)	Qin et al. (2010)	Tyburczy et al. (2015)
NMI	3 (n = 5)	3 (n = 9)	2.5 (n = 31)	2 (n = 8)
Het	3 (n = 92)	2.5 (n = 6)	4 (n = 5)	3 (n = 19)
Mos	2 (n = 14)	3 (n = 16)	2.5 (n = 2)	3 (n = 26)
NMI versus het	p = 0.41	p = 0.95	p = 0.01	p = 0.03
NMI versus mos	p = 0.06	p = 0.26	n/a a	p = 0.03

Abbreviations: DD, developmental disability; Het, heterozygous (including both TSC1 and TSC2 variants); mos, mosaic; n, number; NMI, no mutations identified.

^a Qin et al. did not perform statistical analysis for NMI versus mosaic group due to low numbers.