Table 1.

Summary or reproductive tract variables by study and treatment group

Study		Pre-clinical (n = 57)			Clinical study 1 (n = 80)		Clinical study 2 (n = 40)
Treatment		Control	Early priming	Late priming	Control	Late priming	Control	Early priming
Uterus weight (g)		698 ± 55	163 ± 54*	61 ± 55*	262 ± 48	71 ± 48¥	270 ± 37	55 ± 30ψ
Horn length (mm)		745 ± 82	329 ± 45*	258 ± 55	911 ± 91	487 ± 109¥	765 ± 71	377 ± 49ψ
Ovarian weight (g)		14,6 ± 1,03	4,6 ± 0,99*	2,3 ± 0,36*	10 ± 1,3	3,4 ± 1,3¥	11,0 ± 0,9	3,2 ± 1,2ψ
Follicle size score (%)	0	2	43	80	0	90.48	0	96.23
	1	0	41	20	28.57	0	35.82	0
	2	22	3	0	14.29	0	19.4	0
	3	78	14	0	57.14	9.52	44.78	3.77

SE: Standard error; *Significantly different (P < 0.001) from control animals in the pre-clinical study; ^¥ Significantly different (P = 0.014 for uterus weight; P = 0.013 for horn length; and P = 0.023 for ovarian weight) from control animals in the 1st clinical study

ψ Significantly different (P < 0.001 for all parameters) from control animals in the 2nd clinical study

Follicle size score: 0 = no follicles; 1 = immature; 2 = mature; 3 = mature and luteal tissue