Table 3.
Characteristics of the P. falciparum mono-infected Pfcsp and Pfama-1 amplified isolates genotyped for Pfhrp2/Pfhrp3
| Parameter | All subjects | Pfhrp2-based RDT Status | P value | |
|---|---|---|---|---|
| Positive | False Negative | |||
| DBS Processed | 134 | 97 | 37 | |
| Transmission zone [% (n)] | ||||
| IPT | 93.3 (125) | 91.8 (89) | 97.3 (36) | 0.183 |
| LS | 6.7 (9) | 8.2 (8) | 2.7 (1) | |
| Hrp2/3 gene deletions [% (n)] | ||||
| Pfhrp2 | 34.5 (40) | 16.9 (14) | 78.8 (26) | < 0.001 |
| Pfhrp3 | 23.9 (32) | 8.2 (8) | 64.9 (24) | < 0.001 |
| Pfhrp2-/Pfhrp3- | 23.3 (27) | 7.2 (6) | 63.6 (21) | < 0.001 |
| Pfhrp2-/Pfhrp3+ | 11.2 (13) | 9.6 (8) | 15.2 (5) | 0.292 |
| Pfhrp2+/Pfhrp3- | 2.6 (3) | 1.2 (1) | 6.1 (2) | 0.194 |
| Pfhrp2+/Pfhrp3+ | 62.9 (73) | 81.9 (68) | 15.2 (5) | < 0.001 |
| Ct (Pf), Mean ± SD (range) |
27.3 ± 6.6 (16.3–43.9) |
24.1 ± 3.5 (16.3–31.8) |
35.5 ± 5.9 (24.4–43.9) |
< 0.001 |
| GMPD [range] (parasites/μl blood) |
15,967 [160–405,000] |
20,029 [160–405,000] |
8,523 [400–120,000] |
0.001 |
GMPD = Geometric Mean Parasite Density; LS = Low/Seasonal Transmission; IPT = Intense and Perennial Transmission