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. 2024 Sep 30;15:42. doi: 10.1186/s13229-024-00625-1

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Neural identity of differentiated SETBP1 iPSC clones. A PCA plot demonstrating clear separation between iPSC and NPC samples based on gene expression. B PCA plot comparing SETBP1 experimentally derived NPCs with wild-type NPCs from the ARCHS4 database. C Numbers of DEGs up and downregulated in NPCs defined by SETBP1 genotype. D Analysis of top 50 significant upregulated genes in NPCs compared to iPSCs using Enrichr demonstrated enrichment of neural tissue gene sets in the ARCHS4 tissue database

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