Table 2.
Summary of meta-analysis statistical data for prognostic implications of NUP98 fusions
| Parameters | No. studies | No. patients | Heterogeneity | Model | Meta-analysis | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| I 2 | P | T-au 2 | T-au |
HR
（ 95%CI ） |
Z | P | ||||
| OS | ||||||||||
| Multivariable (NUP98-NSD1) | 4 | 4010 | 96.65 | 0.018 | 0.69 | 0.83 | Random | 2.84 (2.49-3.24) |
15.632 | 0.000 |
| Univariable (NUP98-NSD1) | 2 | 581 | 0.00 | 0.322 | 0.000 | 0.000 | Fixed | 3.67 (2.80-4.82) |
9.418 | 0.000 |
| Multivariable (NUP98-KDM5A) | 6 | 2835 | 0.00 | 0.553 | 0.000 | 0.000 | Fixed | 2.63 2.50-2.81) |
32.89 | 0.000 |
| NUP98-NSD1+FLT3-ITD1 + | 3 | 543 | 60.71 | 0.078 | 0.467 | 0.684 | Random | 2.6 (1.61-4.18) |
3.95 | 0.000 |
| EFS | ||||||||||
| Multivariable (NUP98-NSD1) | 2 | 1486 | 0.00 | 0.335 | 0.00 | 0.00 | Fixed | 2.79 (1.87-4.16) |
5.03 | 0.000 |
| Multivariable (NUP98-KDM5A) | 4 | 422 | 39.86 | 0.173 | 0.146 | 0.382 | Fixed | 2.35 (1.59-3.47) |
4.28 | 0.000 |
| NUP98-NSD1+FLT3-ITD1 + | 3 | 543 | 29.42 | 0.242 | 0.089 | 0.299 | Fixed | 2.82 (1.86-4.26) |
4.93 | 0.000 |