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Paired metastatic biopsies were obtained for patients with mCRPC before the initiation of an ARSI (pre-ARSI) and after radiographic progression on the ARSI (post-ARSI). Two cohorts (WCDT and HMF) were merged, with batch effects corrected as appropriate before downstream analysis. A total of 45 WGS pairs were analyzed, and for a subset of them, RNA-Seq data were successfully generated and analyzed.
