Figure 5. Decreased SSTR1 mRNA in ARSI-resistant mCRPC.

(A) Paired DGE analysis identifies SSTR1 as the most significantly altered gene after ARSI therapy (Wald test, DESeq2). BH, Benjamini-Hochberg procedure. (B) SSTR1 mRNA decreased, while mCRPC developed ARSI resistance in an unpaired analysis using all 71 RNA-Seq samples (Wilcoxon test). (C) SSTR1 downregulation was consistently observed after ARSI across 31 paired samples (paired Wilcoxon test). (D) High SSTR1 expression was associated with survival benefit in 115 WCDT patients who received ARSIs following the biopsy (Wald test).