Table 1.
Baseline characteristics of Sister Study participants by case status, enrolled 2003–2009.
| Characteristics | Ovarian cancer cases () | All ()a |
|---|---|---|
| Age (y) [ (%)] | ||
| 5 (2.0) | 1,966 (4.9) | |
| 40–49 | 52 (20.9) | 10,666 (26.5) |
| 50–59 | 90 (36.1) | 15,701 (38.9) |
| 60–69 | 79 (31.7) | 9,853 (24.4) |
| 70–79 | 23 (9.2) | 2,122 (5.3) |
| Race/ethnicity [ (%)] | ||
| Black, including Hispanic | 20 (8.0) | 3,349 (8.3) |
| Hispanic/Latina | 5 (2.0) | 1,254 (3.1) |
| Non-Hispanic White | 220 (88.4) | 34,401 (85.4) |
| Other racesb | 4 (1.6) | 1,304 (3.2) |
| Educational attainment [ (%)] | ||
| High school or less | 46 (18.5) | 5,734 (14.2) |
| Some college | 87 (34.9) | 13,176 (32.7) |
| College graduate or more | 116 (46.6) | 21,398 (53.1) |
| nSES score [median (IQR)]c | (, 0.38) | (, 0.36) |
| Menopause status [ (%)] | ||
| Premenopausal | 80 (32.1) | 16,458 (40.8) |
| Postmenopausal | 169 (67.9) | 23,845 (59.2) |
| US Census region [ (%)] | ||
| Northeast | 39 (15.7) | 7,389 (18.3) |
| Midwest | 73 (29.3) | 11,040 (27.4) |
| South | 78 (31.3) | 13,105 (32.5) |
| West | 59 (23.7) | 8,774 (21.8) |
| Urbanicity [ (%)] | ||
| Urban | 39 (15.7) | 7,695 (19.1) |
| Suburban | 98 (39.3) | 16,166 (40.1) |
| Rural/small town/other | 112 (45.0) | 16,447 (40.8) |
| 12-month concentrations (ppb) [median (IQR)] | 8.9 (5.8–12.2) | 8.4 (5.8–11.8) |
| 12-month concentrations () [median (IQR)] | 11.0 (8.8–12.8) | 10.7 (8.7–12.4) |
| 12-month concentrations (ppb) [median (IQR)] | 26.3 (24.4–29.0) | 26.6 (24.4–28.8) |
Note: IQR, interquartile ranges; , nitrogen dioxide; nSES, neighborhood socioeconomic status; , ozone; , particulate matter in diameter.
Excluded women who withdrew from the study (), had a prevalent or uncertain ovarian cancer history (), pre-baseline bilateral oophorectomy or unknown number of ovaries removed (), missing air pollutant exposure data (), missing race/ethnicity (), missing educational attainment (), missing nSES score (), missing US Census region (), or zero follow-up time ().
Other races includes American Indian/Alaskan Native, Asian, and Native Hawaiian or other Pacific Islander.
An index developed using 16 tract-level measures of educational attainment, occupation, income, wealth, poverty, employment status, and housing characteristics from the US Census and American Community Survey, with higher index indicating lower nSES and vice versa.