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Humoral immune responses in the vaccinated rabbits. ELISA was performed 3, 6, and 9 months after the inoculation of Ad5-S or RBD-N and SOBERANA as a booster dose. S-specific and N-total antibodies were assessed. Serum samples be diluted at least 1:100. Each dotted graph represents a replicate sample in the rabbit group (p<0.05, two-sided Mann-Whitney U test). AD5.Empty (rAd5 empty), Ad5 S/Boster Soberana (rAd5 S/SOBERANA), Ad5 Mix S & RBD-N (rAd5-S & rAd5 RBD-N mix); OD: optical density
