FIG. 1.

Stroke in rodent and human. A: TTC stained section from mouse with a 2-h suture occlusion of the MCA 1 day after the infarct was induced. The pale area is the infarcted tissue. B: TTC-stained section from rat with a permanent MCAO, one day after infarct was induced. C: T2-weighted MRI from a patient with a malignant infarction. This patient developed malignant edema and required hemicraniectomy. D: T2-weighted image from a patient with an infarct more representative of average human stroke size (Table 2). Panel A is reprinted with permission from Foerch et al. Serum S100B predicts a malignant course of infarction in patients with acute middle cerebral artery occlusion. Stroke 35:2160–2164. Copyright © 2004, Elsevier. All rights reserved.¹⁶⁸ Panel B is reprinted with permission from Kim et al. Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury. Exp Neurol 189:122–130. Copyright © 2004, Lippincott, Williams and Wilkins. All rights reserved.¹⁶⁹ Panel C is courtesy of Dr. Noriko Salamon, Division of Diagnostic Neuroradiology, Geffen School of Medicine at UCLA. Panel D is taken from the authors’ cases in the UCLA Stroke Service, Geffen School of Medicine at UCLA.