Table 2.
Publicly available co-structures with KRAS and an inhibitory molecule
| PDB ID | KRAS mutant | Nucleotide | Inhibitory molecule |
|---|---|---|---|
| 8AZV | KRASWT | GDP | BI-2865 |
| 8TBF | KRASWT | GNP | RMC-7977 + CypA |
| 5F2E | KRASG12C | GDP | ARS-583 |
| 5V9U | KRASG12C | GDP | ARS-1620 |
| 6B0V | KRASG12C | GDP | ARS-107 |
| 6B0Y | KRASG12C | GDP | ARS-917 |
| 6OIM | KRASG12C | GDP | AMG 510 |
| 6USX | KRASG12C | GDP | MRTX849 |
| 5YXZ | KRASG12C | GDP | JBI484 |
| 5YY1 | KRASG12C | GDP | JBI739 |
| 7R0M | KRASG12C | GDP | JDQ443 |
| 8AZX | KRASG12C | GDP | BI-2865 |
| 8G9P | KRASG12C | GNP | RMC-4998 + CypA |
| 8TBK | KRASG12C | GNP | RMC-7977 + CypA |
| 8JGD | KRASG12C | GDP | YK-8S |
| 8DNI | KRASG12C | GDP | Araxes WO2020/028706A1 compound I-1 |
| 7ACA | KRASG12D | GPPCP | BI-5747 |
| 7T47 | KRASG12D | GPPCP | MRTX1133 |
| 8TBL | KRASG12D | GNP | RMC-7977 + CypA |
| 8TBJ | KRASG12R | GNP | RMC-7977 + CypA |
| 8TBN | KRASG12S | GNP | RMC-7977 + CypA |
| 8AZZ | KRASG12V | GDP | BI-2865 |
| 8TBM | KRASG12V | GNP | RMC-7977 + CypA |
| 8B00 | KRASG13D | GDP | BI-2865 |
| 8ONV | KRASG13D | GDP | BI-2493 |
CypA – Cyclophilin A. GDP – guanosine diphosphate. GNP – phosphoaminophosphonic acid-guanylate ester. GPPCP – Guanosine-5′-[(β,γ)-methyleno]triphosphate.