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Recovery and ME of riociguat and M1 in rat plasma (n = 5).
| Analytes | Concentration (ng/mL) | Recovery (%) | Matrix effect (%) | ||
|---|---|---|---|---|---|
| Mean ± SD | RSD (%) | Mean ± SD | RSD (%) | ||
| Riociguat | 2 | 92.3 ± 1.8 | 2.0 | 113.6 ± 5.9 | 5.2 |
| 80 | 99.7 ± 5.8 | 5.8 | 110.7 ± 4.0 | 3.6 | |
| 160 | 93.3 ± 5.7 | 6.1 | 96.4 ± 13.1 | 13.6 | |
| M1 | 1 | 97.7 ± 1.0 | 1.0 | 99.3 ± 3.1 | 3.1 |
| 20 | 98.6 ± 1.8 | 1.8 | 101.5 ± 1.8 | 1.8 | |
| 40 | 99.9 ± 1.0 | 1.0 | 100.1 ± 1.0 | 1.0 | |
