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Stability results of riociguat and M1 in plasma under different conditions (n = 5).
| Analytes | Concentration (ng/mL) | Room temperature, 3 h | Autosampler 10°C, 4 h | Three freeze-thaw | −80°C 3 weeks |
||||
|---|---|---|---|---|---|---|---|---|---|
| RSD (%) | RE (%) | RSD (%) | RE (%) | RSD (%) | RE (%) | RSD (%) | RE (%) | ||
| Riociguat | 2 | 4.8 | 0.6 | 1.1 | 3.5 | 2.2 | 7.1 | 5.7 | 1.1 |
| 80 | 4.7 | 0.9 | 3.7 | 10.3 | 4.8 | 5.0 | 6.1 | −5.8 | |
| 160 | 2.9 | −2.1 | 2.5 | 7.8 | 3.2 | 4.3 | 4.3 | 7.0 | |
| M1 | 1 | 2.6 | −4.0 | 2.8 | −10.8 | 2.1 | 0.8 | 4.5 | 4.5 |
| 20 | 2.2 | −3.9 | 3.3 | 6.4 | 4.1 | 7.6 | 1.8 | −10.9 | |
| 40 | 3.5 | −2.0 | 2.5 | 11.2 | 3.0 | 13.9 | 3.8 | 9.1 | |
