TABLE 4.
Main pharmacokinetic parameters of riociguat in the two groups of SD rats (n = 4, mean ± SD).
| Parameters | Riociguat | Riociguat + Quercetin |
|---|---|---|
| AUC(0-t) (ng/mL a h) | 1763.67 ± 373.10 | 2,846.97 ± 616.18 a |
| AUC(0-∞) (ng/mL a h) | 1771.82 ± 372.94 | 3044.92 ± 537.01 b |
| t1/2z (h) | 4.18 ± 0.76 | 9.68 ± 2.57 b |
| Tmax (h) | 3.34 ± 3.08 | 9.75 ± 4.50 |
| CLz/F (L/h/kg) | 2.94 ± 0.74 | 1.68 ± 0.32 a |
| Cmax (ng/mL) | 214.80 ± 50.40 | 156.73 ± 55.89 |
a
p < 0.05.
b
p < 0.01.
c
Compared with the Group riociguat. AUC: area under the plasma concentration-time curve; t1/2z: elimination half time; Tmax: peak time; CLz/F: plasma clearance; Cmax: maximum plasma concentration.