TABLE 5.
Main pharmacokinetic parameters of M1 in the two groups of SD rats (n = 4, mean ± SD).
| Parameters | Riociguat | Riociguat + Quercetin |
|---|---|---|
| AUC(0-t) (ng/mL a h) | 228.62 ± 36.54 | 328.30 ± 68.16 a |
| AUC(0-∞) (ng/mL a h) | 229.38 ± 36.18 | 436.66 ± 107.33 a |
| t1/2z (h) | 3.96 ± 0.58 | 12.78 ± 5.29 a |
| Tmax (h) | 5.25 ± 2.99 | 9.75 ± 4.50 |
| Cmax (ng/mL) | 23.06 ± 5.84 | 16.22 ± 5.20 |
a
p < 0.05.
b
p < 0.01.
c
Compared with the Group riociguat. AUC: area under the plasma concentration-time curve; t1/2z: elimination half time; Tmax: peak time; Cmax: maximum plasma concentration.