Table 2.

Clinical complications associated with honeybee stings envenoming in the entire patient cohort and in patients who died.

Case	Age	Sex	Country	Number of Stings	Time to Treatment	Time to Death	Comorbidity	Clinical complications	System	Reference
1	10	Male	Turkey	5989	3 h	12 days	–	Acute kidney failure Acute respiratory distress syndrome (ARDS) Convulsion Hemolysis Hypertension Ischemic stroke Multiorgan failure	Nervous Hematologic Respiratory Urinary Multiorgan	(134)
2	8	Male	Nigeria	–	50 min	36 h	Sickle cell anemia	Hematuria Hemolysis	Hematologic	(130)
3	25	Male	Australia	1	–	40 h	–	Acute respiratory distress syndrome (ARDS) Anaphylactic shock Bleeding Cerebral tonsillar herniation Disseminated intravascular coagulation (DIC) Hematuria Ischemic hepatitis Myocardial damage	Cardiovascular Hepatic Hematologic Immune Nervous Urinary Respiratory	(133)
4	38	Male	South Africa	32	–	–	–	Subarachnoid hemorrhage Subendocardial hemorrhage	Cardiovascular Nervous	(121)
5	58	Male	South Africa	1	–	–	–	Laryngeal edema Left ventricular hypertrophy Pulmonary congestion Pulmonary edema	Cardiovascular Respiratory	(121)
6	58	Male	South Africa	10	No medical care	–	–	Anaphylactic shock	Immune	(121)
7	38	Female	Hungary	1	No medical care	4 min	–	Acute respiratory distress syndrome (ARDS) Anaphylactic shock	Immune Respiratory	(73)
8	25	Male	Australia	1	–		Asthma	Cardiorespiratory arrest Laryngeal edema Pulmonary congestion	Cardiovascular Respiratory	(139)
9	36	Female	Australia	40-50	15 min	>29 min	Asthma Psoriasis	Cardiorespiratory arrest Laryngeal edema	Cardiovascular Respiratory	(139)
10	54	Male	Australia	1	15 min	>15 min	Osteoporosis	Cardiorespiratory arrest Laryngeal edema Pulmonary congestion Pulmonary edema	Cardiovascular Respiratory	(139)
11	70	Male	Brazil	–	20 h	–	Diabetes Hypertension	Acute respiratory distress syndrome (ARDS) Anuria Cardiorespiratory arrest	Cardiovascular Respiratory Urinary	(18)
12	39	Male	Honduras	–	3 h	37 h	–	Anaphylactic shock Anuria Rhabdomyolysis	Immune Multiorgan Muscular Urinary	(145)
13	19	Male	Brazil	2000	0 h	23 days	–	Acute respiratory distress syndrome (ARDS) Anuria Cardiorespiratory arrest Pericardial effusion Pulmonary edema Shock	Cardiovascular Hematologic Urinary Respiratory	(125)
14	46	Female	Brazil	1	2 h	2 h	Obesity	Anaphylactic shock Bleeding Subarachnoid hemorrhage Pulmonary edema Pulmonary hemorrhage	Hematologic Immune	(4)
15	48	Male	Turkey	–	–	3 days	–	Encephalitis Hepatitis Gastrointestinal haemorrhage	Digestory Hepatic Nervous	(128)
16	59	Male	Italy	–	–	–	–	Bronchial obstruction Cardiorespiratory arrest Laryngeal edema Pulmonary congestion Pulmonary edema Pulmonary emphysema Pulmonary hemorrhage	Cardiovascular Respiratory	(141)
17	67	Male	Iran	20	3 days	5 days	Type-2 diabetes Hypertension Myocardial infarction Ventricular aneurysm	Cardiorespiratory arrest Thrombotic thrombocytopenic purpura (TTP)	Cardiovascular Hematologic Respiratory	(137)
18	59	Male	India	–	–	5 days	Parkinson disease	Adrenal hemorrhage Laryngeal congestion Laryngeal edema Tracheal congestion Tracheal edema Pulmonary congestion Pulmonary edema Rhabdomyolysis	Muscular Urinary Respiratory	(138)
19	42	Male	Iran	–	–	30 min – 1 h	–	Anaphylactic shock Cardiorespiratory arrest	Cardiovascular Immune Respiratory	(143)
20	41	Female	India	1	3 h	7 days	–	Disseminated intravascular coagulation (DIC) Hemiparesis Hemorrhagic/Ischemic stroke	Hematologic Nervous	(149)
21	66	Male	Argentina	>500	–	36 h	Hypertension	Anaphylactic shock Multiorgan failure	Immune Multiorgan	(203)