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. 2024 Aug 12;9(10):2506–2521. doi: 10.1038/s41564-024-01769-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, RNA transcripts from S. aureus Atopic Dermatitis (AD) clinical isolates. b, Carbon utilization assays shown as fold-change increase w.r.t. WT. c, Growth curves in CDM ± 100 μM proline. d, Bacterial burden and e, skin lesion size at 6 days post-infection from a 5 mm punch biopsy of skin infected with S. aureus Newman. f, Host RNA transcripts from 5 mm punch biopsy of skin infected with S. aureus Newman. g-h, Putative cre binding sites in S. aureus atopic dermatitis (AD) isolates AD2 and AD8 for ccpA in silico (black dashes, mismatches; red dots, matches) using binding sequences Sequence 1 and Sequence 2 (red). i, Bacterial burden at 6 days post- infection from a 5 mm punch biopsy of skin infected with WT JE2, ccpA::Tn, ccpE::Tn, putP::Tn. Data presented as mean ± SEM, (a-c) n = 3, (d,e) n = 4, (i) n = 3. Significance determined by *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, (a,c,e) Two-Way ANOVA with Dunnett’s Multiple Comparisons, (b,d) two-tailed t- Student with Kolmogrov-Smirnov test (f,i) One-Way. ANOVA with Tukey’s Multiple Comparisons.