FIGURE 1.

Classification of nanodiscs, membrane protein drug discovery, and drug incorporation. (A) Four main categories of nanodiscs: (a) MSP and MSP nanodiscs (b) Saposin and Saposin nanodiscs (c) Small peptides and peptide nanodiscs (d) Copolymers and copolymer nanodiscs. (B) Schematic diagram of antibody discovery using phage display technology for MSP nanodiscs (C) (a) Some drugs are covalently bound to nanodiscs (b) The lipids or belts of nanodiscs are modified to achieve coupling or targeting functions (c) Some targeted drugs are inserted into modified nanodiscs.