Figure 6.
Markers of RBC physiology (OL cohort). Scatterplots for PoS (A), Elmin (B), Elmax (C), and (hyper) DRBCs (D) at BL and EOT. Each data point corresponds to data from 1 patient. Paired BL and EOT data points from each patient are connected by a line. Median BL and EOT values shown in green and blue diamonds, respectively. P values are from a Wilcoxon matched-pairs signed rank test. Percent hyper RBC is defined as the percent of RBCs with >41 g/dL of Hb. BL, baseline; DRBCs, dense RBCs; EI, elongation index; Elmax, maximum EI; Elmin, minimum EI; EOT, end of treatment; OL, open-label; PoS, point of sickling; RBC, red blood cell.