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. 2024 Oct 1;15(10):720. doi: 10.1038/s41419-024-07104-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Volcano plot of differential gene distribution after NOD2 overexpression in SK-MEL-110 melanoma cells. B, C GO analysis of the top 30 downregulated genes (B) and KEGG analysis of the top 20 downregulated genes (C) in NOD2 overexpressing SK-MEL-110 melanoma cells. D, E GEPIA database analysis of mRNA expression of TYMS and PLK1 in melanoma and normal tissues. F, G Real-time PCR determination of mRNA expression of TYMS, PLK1 after NOD2 overexpression and knockdown in A875 and SK-MEL-110 cells (F) and Western blot determination of protein levels of TYMS, PLK1, and p-PLK1 (G). H ELISA kit evaluates TYMS activity after NOD2 overexpression and knockdown in A875 and SK-MEL-110 cells. Data are expressed as the mean ± SD. Student’s t-test and one-way ANOVA were used to compare the differences. *P < 0.05, **P < 0.01, ***P < 0.001.