Table 4.
Contingency table and diagnostic accuracy on per-region analysis over a total of 174 anatomical lymph nodal regions dissected in 30 patients according to different definitions of PSMA-RGS positivity at in vivo only evaluation
| Pathology positive | Pathology negative | |
|---|---|---|
| Positivity ≥ 2 target-to-background ratio | ||
| PSMA-RGS positive | 16 | 17 |
| PSMA-RGS negative | 6 | 135 |
| Sensitivity | 72% (50–89%) | |
| Specificity | 88% (83–89%) | |
| Positive Predictive Value | 48% (31–66%) | |
| Negative Predictive Value | 96% (91–98%) | |
| Accuracy | 87% (81–91%) | |
| Positivity ≥ 3 target-to-background ratio | ||
| PSMA-RGS positive | 12 | 3 |
| PSMA-RGS negative | 10 | 149 |
| Sensitivity | 54% (32–76%) | |
| Specificity | 98% (94–100%) | |
| Positive Predictive Value | 80% (52–96%) | |
| Negative Predictive Value | 93% (89–97%) | |
| Accuracy | 92% (88–96%) | |
| Positivity ≥ 4 target-to-background ratio | ||
| PSMA-RGS positive | 8 | 1 |
| PSMA-RGS negative | 14 | 151 |
| Sensitivity | 36% (17–59%) | |
| Specificity | 99% (96–100%) | |
| Positive Predictive Value | 89% (52–100%) | |
| Negative Predictive Value | 91% (86–95%) | |
| Accuracy | 91% (86–95%) | |