Table 5.
Contingency table and diagnostic accuracy on per-patient analysis over a total of 30 patients according to different definitions of PSMA-RGS positivity at in vivo evaluation
| Pathology positive | Pathology negative | |
|---|---|---|
| Positivity ≥ 2 target-to-background ratio | ||
| PSMA-RGS positive | 7 | 5 |
| PSMA-RGS negative | 2 | 16 |
| Sensitivity | 78% (40–96%) | |
| Specificity | 76% (53–92%) | |
| Positive Predictive Value | 58% (28–85%) | |
| Negative Predictive Value | 89% (65–99%) | |
| Accuracy | 77% (58–90%) | |
| Positivity ≥ 3 target-to-background ratio | ||
| PSMA-RGS positive | 6 | 1 |
| PSMA-RGS negative | 3 | 20 |
| Sensitivity | 66% (30–93%) | |
| Specificity | 95% (76–100%) | |
| Positive Predictive Value | 86% (42–100%) | |
| Negative Predictive Value | 87% (66–97%) | |
| Accuracy | 87% (69–96%) | |
| Positivity ≥ 4 target-to-background ratio | ||
| PSMA-RGS positive | 5 | 1 |
| PSMA-RGS negative | 4 | 20 |
| Sensitivity | 55% (21–86%) | |
| Specificity | 95% (76–100%) | |
| Positive Predictive Value | 83% (36–100%) | |
| Negative Predictive Value | 83% (63–95%) | |
| Accuracy | 83% (65–94%) | |