Fig. 3.

Fabricating CMNDDs by cellular internalization in vitro. (A) The change of CD80 expression in each group after 24 h incubation with DMEM medium and M2 culture medium. (B) The CD80 ratio in Mø+M2 medium, M1 + M2 medium, Fe₃O₄@M1 + M2 medium, Fe₃O₄-SWCNT@M1 + M2 medium group; (C) CD80 expression in freshly harvested M2 with different co-culture processes for 24 h; (D) The specific cleavage of 4T1 tumor cells in different groups by LDH method. A-D are preprinted with the permission from Elsevier Ref [58]. (E) Toxicity of MTP-BPLP-PLA and MTP-BPLP-PLA-PLX4032 nanoparticles to THP-1, WM35, and 1205Lu cells after 7 d of incubation. (F) THP-1-mediated nanoparticles delivery and drug release effects on melanoma cells with different THP-1 to melanoma cell (2000 cells per well) ratios after 7 d of incubation. #p < 0.01 compared to controls; *p < 0.01 between two groups. E and F are preprinted with the permission from Wiley-VCH GmbH Ref [59]